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Article

c-Abl expression in chronic lymphocytic leukemia cells: clinical and therapeutic implications.

Cancer research - 1 Aug 2006

Lin Ke, Glenn Mark A, Harris Robert J, Duckworth Andrew D, Dennett Sally, Cawley John C, Zuzel Mirko, Slupsky Joseph R

Abstract excerpt

c-Abl is important for normal B-cell development, but little is known about the function of this nonreceptor tyrosine kinase in chronic lymphocytic leukemia (CLL). Therefore, the aim of the present study was to examine the clinical, therapeutic, and pathogenetic importance of c-Abl in this disease. We show that the malignant cells of CLL predominantly express the type 1b splice variant of c-Abl and that the...

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Source

Identifiers

PMID: 16885384
DOI: 10.1158/0008-5472.CAN-05-3901

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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