Article
Chronic mucocutaneous candidiasis with deficient CD2 (E receptor) but normal CD3 mononuclear cells.
Journal of clinical & laboratory immunology - 1 Jun 1991
Noh L M, Hussein S H, Sukumaran K D, Rose I, Abdullah N
Abstract excerpt
A case of chronic mucocutaneous candidiasis in a Malaysian child who subsequently developed disseminated tuberculosis and toxoplasmosis is described. The phenotype of her peripheral blood mononuclear cells showed discordance for her T cell markers. The presence of a subpopulation of CD2-/CD3+ mononuclear cells leading to an immunodeficiency state is consistent with failure of activation of CD2-mediated...
Topics
- Antigens, Differentiation, T-Lymphocyte
- CD2 Antigens
- CD3 Complex
- Candidiasis, Chronic Mucocutaneous
- Candidiasis, Oral
- Disease Susceptibility
- Female
- Genetic Predisposition to Disease
- Humans
- Immunocompromised Host