Article
A novel mutation of varicella-zoster virus associated to fatal hepatitis.
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology - 1 Sept 2006
Natoli Silvia, Ciotti Marco, Paba Pierpaolo, Testore Gian Piero, Palmieri Giampiero, Orlandi Augusto, Sabato Alessandro Fabrizio, Leonardis Francesca
Abstract excerpt
BACKGROUND: Lethal varicella in immunocompetent hosts is rare and its pathogenesis is largely unknown. The discovery of glycoprotein E (gE) mutants showing attributes consistent with increased virulence in vitro and in animal models, provided a possible molecular mechanism underlying a more aggressive virus infection. However, these mutants have never been associated with unusually severe clinical cases....
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