An intronic variable number of tandem repeat polymorphisms of the cold-induced autoinflammatory syndrome 1 (CIAS1) gene modifies gene expression and is associated with essential hypertension.

doi:10.1038/sj.ejhg.5201698

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Article

An intronic variable number of tandem repeat polymorphisms of the cold-induced autoinflammatory syndrome 1 (CIAS1) gene modifies gene expression and is associated with essential hypertension.

European journal of human genetics : EJHG - 1 Dec 2006

Omi Toshinori, Kumada Maki, Kamesaki Toyomi, Okuda Hiroshi, Munkhtulga Lkhagvasuren, Yanagisawa Yoshiko, Utsumi Nanami, Gotoh Takaya, Hata Akira, Soma Masayoshi, Umemura Satoshi, Ogihara Toshio, Takahashi Norio, Tabara Yasuharu, Shimada Kazuyuki, Mano Hiroyuki, Kajii Eiji, Miki Tetsuro, Iwamoto Sadahiko

Abstract excerpt

Cold-induced autoinflammatory syndrome 1 (CIAS1) gene is a member of the NALP subfamily of the CATERPILLER protein family that is expressed predominantly in peripheral blood leukocytes, which is to regulate apoptosis or inflammation through the activation of NF-kappaB and caspase. Recent genetic analyses suggested an association between inflammation and oxidative stress-related genes in the development of...

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PMID: 16868559
DOI: 10.1038/sj.ejhg.5201698

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