Article
Constitutive activation of neuregulin/ERBB3 signaling pathway in clear cell sarcoma of soft tissue.
Neoplasia (New York, N.Y.) - 1 Jul 2006
Schaefer Karl-Ludwig, Brachwitz Kristin, Braun Yvonne, Diallo Raihanatou, Wai Daniel H, Zahn Susanne, Schneider Dominik T, Kuhnen Cornelius, Vollmann Arabel, Brockhoff Gero, Gabbert Helmut E, Poremba Christopher
Abstract excerpt
Clear cell sarcoma of soft tissue (CCSST) represents a highly malignant tumor of the musculoskeletal system that is characterized by the chromosomal translocation t(12;22)(q13;q12) of the Ewing sarcoma gene (EWSR1) and activating transcription factor 1 (ATF1). In a former microarray expression study, we identified ERBB3, a member of the epidermal growth factor receptor (EGFR) family, as a promising new diagnostic...
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