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Article

ETR‐3 represses Tau exons 2/3 inclusion, a splicing event abnormally enhanced in myotonic dystrophy type I

21 Jul 2006

Abstract excerpt

Altered splicing of transcripts, including the insulin receptor (IR) and the cardiac troponin (cTNT), is a key feature of myotonic dystrophy type I (DM1). CELF and MBNL splicing factor members regulate the splicing of those transcripts. We have previously described an alteration of Tau exon 2 splicing in DM1 brain, resulting in the favored exclusion of exon 2. However, the factors required for alternative...

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PMID: 16862542
DOI: 10.1002/jnr.20980

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Related research

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ETR‐3 represses Tau exons 2/3 inclusion, a splicing event abnormally enhanced in myotonic dystrophy type IPMID 16862542Read ↗

Repression of nuclear CELF activity can rescue CELF-regulated alternative splicing defects in skeletal muscle models of myotonic dystrophySemantic proximity Read ↗

Mis-splicing of Tau exon 10 in myotonic dystrophy type 1 is reproduced by overexpression of CELF2 but not by MBNL1 silencingSemantic proximity Read ↗

Modulation of the membrane-binding domain of tau protein: splicing regulation of exon 2.Semantic proximity Read ↗

Expression of a dominant negative CELF protein in vivo leads to altered muscle organization, fiber size, and subtype.Semantic proximity Read ↗

The CELF Family of RNA Binding Proteins Is Implicated in Cell-Specific and Developmentally Regulated Alternative SplicingSemantic proximity Read ↗

Alternative splicing of myomesin 1 gene is aberrantly regulated in myotonic dystrophy type 1.Semantic proximity Read ↗

Cardiac elav-type RNA-binding protein (ETR-3) binds to RNA CUG repeats expanded in myotonic dystrophySemantic proximity Read ↗

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<i>ABLIM1</i> splicing is abnormal in skeletal muscle of patients with <scp>DM</scp>1 and regulated by <scp>MBNL</scp>,<scp> CELF</scp> and <scp>PTBP</scp>1Semantic proximity Read ↗

Regulated tissue-specific alternative splicing of enhanced green fluorescent protein transgenes conferred by alpha-tropomyosin regulatory elements in transgenic mice.Semantic proximity Read ↗

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