A Chemical Proteomics Approach for the Identification of Accessible Antigens Expressed in Human Kidney Cancer

Abstract excerpt

A promising avenue toward the development of more selective anticancer drugs consists in the targeted delivery of bioactive molecules to the tumor environment by means of binding molecules specific to tumor-associated markers. We have used a chemical proteomics approach based on the ex vivo perfusion and biotinylation of accessible structures within surgically resected human kidneys with tumor to gain information...

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