Article
Chronic multifocal osteomyelitis, a new recessive mutation on chromosome 18 of the mouse.
Genomics - 1 Dec 1991
Byrd L, Grossmann M, Potter M, Shen-Ong G L
Abstract excerpt
Mice with tail kinks and deformities in their lower extremities were observed in a litter of C.D2-Qa-2+N6F15 mice. A mutant line that exhibits this phenotype in 100% of its offspring was established by subsequent breeding. The abnormalities resembled to some degree those found in a human syndrome termed chronic recurrent multifocal osteomyelitis (CRMO). Accordingly, we name the new mutation chronic multifocal...
Topics
- Animals
- Chromosome Mapping
- Chronic Disease
- Crosses, Genetic
- Female
- Genes, Recessive
- Male
- Mice
- Mutation
- Osteomyelitis
- Phenotype
- Polymorphism, Restriction Fragment Length