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Article

Null mutations of NEUROG3 are associated with delayed-onset diabetes mellitus.

JCI insight - 16 Jan 2020

Solorzano-Vargas R Sergio, Bjerknes Matthew, Wang Jiafang, Wu S Vincent, Garcia-Careaga Manuel G, Pitukcheewanont Pisit, Cheng Hazel, German Michael S, Georgia Senta, Martín Martín G

Abstract excerpt

Biallelic mutations of the gene encoding the transcription factor NEUROG3 are associated with a rare disorder that presents in neonates as generalized malabsorption - due to a complete absence of enteroendocrine cells - followed, in early childhood or beyond, by insulin-dependent diabetes mellitus (IDDM). The commonly delayed onset of IDDM suggests a differential requirement for NEUROG3 in endocrine cell...

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Identifiers

PMID: 31805014
DOI: 10.1172/jci.insight.127657
PMCID: PMC7030873

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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