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Article

Methylation mediated silencing of TMS1/ASC gene in prostate cancer

18 Jul 2006

Abstract excerpt

BACKGROUND: Transcriptional silencing associated with aberrant promoter methylation has been established as an alternate pathway for the development of cancer by inactivating tumor suppressor genes. TMS1 (Target of Methylation induced Silencing), also known as ASC (Apoptosis Speck like protein containing a CARD) is a tumor suppressor gene which encodes for a CARD (caspase recruitment domain) containing regulatory...

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PMID: 16848908
DOI: 10.1186/1476-4598-5-28

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