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Article

Gene expression analysis of B‐lymphoma cells resistant and sensitive to bortezomib*

26 May 2006

Abstract excerpt

The proteasome inhibitor bortezomib has shown impressive clinical activity alone and in combination with conventional and other novel agents for the treatment of multiple myeloma (MM). Although bortezomib is known to be a selective proteasome inhibitor, the downstream mechanisms of cytotoxicity and drug resistance are poorly understood. However, resistance to bortezomib as a single agent develops in the majority...

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PMID: 16846475
DOI: 10.1111/j.1365-2141.2006.06132.x

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