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Article

Cloning, expression, and protein interaction of human nebulin fragments composed of varying numbers of sequence modules.

1 Nov 1991

Abstract excerpt

Nebulin, a family of giant myofibrillar proteins of 600-900 kDa, contains a large number of highly conserved sequence repeats of 31-38 amino acids. To investigate the significance of this repeat, human skeletal muscle nebulin cDNA fragments encoding two, six, seven, eight, or fifteen repeat modules were expressed in high yield as nonfusion proteins in Escherichia coli with the pET3d plasmid vector. F-actin...

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PMID: 1682316
DOI: 10.1016/s0021-9258(18)54843-2

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