Article
Simulation of normal, carrier and affected controls for large-scale genotyping of cattle for factor XI deficiency.
Genetics and molecular research : GMR - 30 Jun 2006
Mukhopadhyaya P N, Jha M, Muraleedharan P, Gupta R R, Rathod R N, Mehta H H, Khoda V K
Abstract excerpt
An insertion mutation within exon 12 of the factor XI gene has been described in Holstein cattle. This has opened the prospect for large-scale screening of cattle using the polymerase chain reaction (PCR) technique for the rapid identification of heterozygous animals. To facilitate such a screening process, the mutant and normal alleles of factor XI gene, represented by 244- and 320-bp PCR amplified fragments,...
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