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Infection of Naive Target Cells with Virus-Like Particles: Implications for the Function of Ebola Virus VP24

29 Jun 2006

Abstract excerpt

Infectious virus-like particle (iVLP) systems have recently been established for several negative-strand RNA viruses, including the highly pathogenic Zaire ebolavirus (ZEBOV), and allow study of the viral life cycle under biosafety level 2 conditions. However, current systems depend on the expression of viral helper nucleocapsid proteins in target cells, thus making it impossible to determine whether...

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PMID: 16809331
DOI: 10.1128/jvi.00051-06

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