Article
Nucleotide sequence evidence of the unicentric origin of the beta C mutation in Africa.
Human genetics - 1 Sept 1991
Trabuchet G, Elion J, Dunda O, Lapouméroulie C, Ducrocq R, Nadifi S, Zohoun I, Chaventre A, Carnevale P, Nagel R L
Abstract excerpt
The origin of the beta C mutation was studied by characterizing nucleotide sequence polymorphisms on beta C chromosomes of patients from various African countries. In the majority of cases, the beta C mutation was found in linkage disequilibrium with a single chromosomal structure as defined by classical RFLP haplotypes, intergenic nucleotide sequence polymorphisms immediately upstream of the beta-globin gene,...
Topics
- Africa
- Base Sequence
- DNA
- Globins
- Haplotypes
- Humans
- Molecular Sequence Data
- Mutation
- Polymorphism, Restriction Fragment Length
- Repetitive Sequences, Nucleic Acid