Article
Haplotypes in the dystrophin DNA segment point to a mosaic origin of modern human diversity.
American journal of human genetics - 1 Nov 2003
Zietkiewicz Ewa, Yotova Vania, Gehl Dominik, Wambach Tina, Arrieta Isabel, Batzer Mark, Cole David E C, Hechtman Peter, Kaplan Feige, Modiano David, Moisan Jean-Paul, Michalski Roman, Labuda Damian
Abstract excerpt
Although Africa has played a central role in human evolutionary history, certain studies have suggested that not all contemporary human genetic diversity is of recent African origin. We investigated 35 simple polymorphic sites and one T(n) microsatellite in an 8-kb segment of the dystrophin gene. We found 86 haplotypes in 1,343 chromosomes from around the world. Although a classical out-of-Africa topology was...
Topics
- Africa
- Alleles
- Base Sequence
- Chromosomes, Human
- Dystrophin
- Evolution, Molecular
- Genetic Variation
- Geography
- Haplotypes
- Humans
- Microsatellite Repeats
- Molecular Sequence Data
- Mosaicism