Article
Progression of the cell cycle through mitosis leads to abortion of nascent transcripts.
Cell - 18 Oct 1991
Shermoen A W, O'Farrell P H
Abstract excerpt
Nascent transcripts of the Drosophila Ubx gene were detected by in situ hybridization. Following onset of expression, the progress of RNA polymerase (1.4 kb/min) across the gene was visualized as the successive appearance of hybridization signals from different positions within the transcription unit. Nascent transcripts disappeared at mitosis. Hybridization signals reappeared in the next cell cycle first with a...
Topics
- Alkaline Phosphatase
- Animals
- Cell Nucleus
- DNA Probes
- Digoxigenin
- Drosophila melanogaster
- Gene Expression Regulation
- Genes, Homeobox
- Mitosis
- Mutation
- Nucleic Acid Hybridization
- Transcription, Genetic