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Article

Alsin/Rac1 signaling controls survival and growth of spinal motoneurons.

Annals of neurology - 1 Jul 2006

Jacquier Arnaud, Buhler Emmanuelle, Schäfer Michael K E, Bohl Delphine, Blanchard Stephane, Beclin Christophe, Haase Georg

Abstract excerpt

OBJECTIVE: Recessive mutations in alsin, a guanine-nucleotide exchange factor for the GTPases Rab5 and Rac1, cause juvenile amyotrophic lateral sclerosis (ALS2) and related motoneuron disorders. Alsin function in motoneurons remained unclear because alsin knock-out mice do not develop overt signs of motoneuron degeneration. METHODS: To generate an alsin loss-of-function model in an ALS-relevant cell type, we...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16802292
DOI: 10.1002/ana.20886

Genes

ALS2
EEA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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