Article
Wide mutational spectrum of a gene involved in hormone action and insecticide resistance in Drosophila melanogaster.
Molecular genetics and genomics : MGG - 1 Sept 2006
Wilson Thomas G, Wang Shaoli, Beno Milan, Farkas Robert
Abstract excerpt
The Methoprene-tolerant (Met) bHLH-PAS gene in Drosophila melanogaster is involved in the molecular action of juvenile hormone (JH), and mutants result in resistance to the toxic and morphogenetic effects of JH and JH agonist insecticides such as methoprene. A detailed study of Met mutants can shed light on the poorly understood action of JH as well as the molecular basis of Met resistance to JH insecticides....
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