Article
[Analysis of X ba I polymorphism of FVIII gene and its application on prenatal diagnosis for hemophilia A].
Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi - 1 Mar 2006
Wang Zhan-yong, Liang Yan, Zhou Yan, Xiao Bai, Liu Jing-zhong
Abstract excerpt
OBJECTIVE: To establish the linkage methods of X ba I polymorphisms specific for FVIII gene intron 22, and to find a rapid and simple system for haemophilia A (HA) carrier detection and prenatal diagnosis. METHODS: A long PCR to amplify FVIII gene intron 22 followed by X ba I digestion was used to assay the gene rate and heterozygosity rate of 206 unrelated people. Detection of intron 22 inversion by long...
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