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Article

[FVIII intron 22 homologous region mediated recombinations and genotyping methods of hemophilia A].

Zhongguo shi yan xue ye xue za zhi - 1 Jun 2014

Guo Zhi-Ping, Yang Lin-Hua

Abstract excerpt

The intron 22 inversion is caused by intrachromosomal homologous recombination of the Int22h (intron 22 homologous region) repeats in opposite orientation, accounting for almost 45%-50% of all cases of severe hemophilia A. By contrast, recombinations between similarly oriented int22h repeats in the same chromosome, homologous chromosomes or chromatids may cause deletion or duplication of the intermediate region...

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Share to Factor VIII
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 24989311
DOI: 10.7534/j.issn.1009-2137.2014.03.055

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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