ATP-binding cassette transporter-2 (ABCA2) as a therapeutic target.

doi:10.1016/j.bcp.2017.11.018

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Article

ATP-binding cassette transporter-2 (ABCA2) as a therapeutic target.

Biochemical pharmacology - 1 May 2018

Davis Warren, Tew Kenneth D

Abstract excerpt

The ATP binding cassette transporter ABCA2 is primarily an endolysosomal membrane protein that demonstrates pleiotropic functionalities, coalescing around the maintenance of homeostasis of sterols, sphingolipids and cholesterol. It is most highly expressed in brain tissue and ABCA2 knockout mice express neurological defects consistent with aberrant myelination. Increased expression of the transporter has been...

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Identifiers

PMID: 29223352
DOI: 10.1016/j.bcp.2017.11.018
PMCID: PMC5899931

Genes

ABCA2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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