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Article

Wangiella (Exophiala) dermatitidis WdChs5p, a class V chitin synthase, is essential for sustained cell growth at temperature of infection.

Eukaryotic cell - 1 Feb 2004

Liu Hongbo, Kauffman Sarah, Becker Jeffrey M, Szaniszlo Paul J

Abstract excerpt

The chitin synthase structural gene WdCHS5 was isolated from the black fungal pathogen of humans Wangiella dermatitidis. Sequence analysis revealed that the gene has a myosin motor-like-encoding region at its 5' end and a chitin synthase (class V)-encoding region at its 3' end. Northern blotting showed that WdCHS5 is expressed at high levels under conditions of stress. Analysis of the 5' upstream region of WdCHS5...

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Identifiers

PMID: 14871935
DOI: 10.1128/EC.3.1.40-51.2004
PMCID: PMC329517

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