Article
Interaction between serotonin 2A receptor and endothelin-1 variants in association with hypertension in Japanese.
Hypertension research : official journal of the Japanese Society of Hypertension - 1 Apr 2006
Yamamoto Miyuki, Jin Jing Ji, Wu Zhihong, Abe Michiko, Tabara Yasuharu, Nagai Tokihisa, Yamasaki Eiji, Igase Michiya, Kohara Katsuhiko, Miki Tetsuro, Nakura Jun
Abstract excerpt
Serotonin has been implicated in the pathogenesis of hypertension because of its ability to induce vasoconstriction via stimulation of serotonin 2 (5-HT2) receptors. Recently, an association between the T102C functional polymorphism of the serotonin 2A (5-HT2A) receptor gene and hypertension in the UK has been reported. Another association study, however, failed to replicate this association in a Chinese...
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