Article
Strong association of MuSK antibody-positive myasthenia gravis and HLA-DR14-DQ5.
Neurology - 13 Jun 2006
Niks E H, Kuks J B M, Roep B O, Haasnoot G W, Verduijn W, Ballieux B E P B, De Baets M H, Vincent A, Verschuuren J J G M
Abstract excerpt
The authors studied the HLA profile of 23 white Dutch patients with muscle-specific kinase antibody-positive myasthenia gravis (MuSK Ab+ MG) and found an association with HLA-DR14-DQ5 (odds ratio 8.5; 95% CI 3.9 to 18.7; p = 4.9 x 10(-5)). Fifty-two percent of the patients carried the DR14 allele compared with 5% of the controls (p = 1.0 x 10(-8)). This association between MuSK Ab+ MG and a relatively rare HLA...
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