Article
Germline repertoire of T-cell receptor beta-chain genes in patients with insulin-dependent diabetes mellitus.
Human immunology - 1 Jun 1991
Martínez-Naves E, Coto E, Gutiérrez V, Urra J M, Setién F, Domínguez O, Hood L E, López-Larrea C
Abstract excerpt
We have investigated the genotype and allelic distribution of germline restriction fragment length polymorphisms of the T-cell receptor beta chain, segment C beta, and two variable segments which are in linkage disequilibrium, V beta 8 and V beta 11, in 42 insulin-dependent diabetes mellitus (IDDM) patients and in 51 healthy blood donors used as controls. Recently, several works have reported contradictory...
Topics
- Adolescent
- Alleles
- Child
- Child, Preschool
- DNA
- DNA Probes
- Diabetes Mellitus, Type 1
- Electrophoresis, Polyacrylamide Gel
- Genotype
- Haplotypes
- Humans