Article
Prospective results of surveillance colonoscopy in dominant familial colorectal cancer with and without Lynch syndrome.
Gastroenterology - 1 Jun 2006
Dove-Edwin Isis, de Jong Andrea E, Adams Joanna, Mesher David, Lipton Lara, Sasieni Peter, Vasen Hans F A, Thomas Huw J W
Abstract excerpt
BACKGROUND & AIMS: Lynch syndrome is an autosomal dominant predisposition to colorectal cancer caused by mutations in DNA mismatch repair genes; colorectal cancer risk is high. Few studies have addressed colorectal cancer risk in individuals from dominant families without mismatch repair deficiency. We sought to establish whether these individuals are also at increased risk by examining the incidence of advanced...
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