Article
RFLP analysis with cDNA probes for DQ/DP region in HLA identical sibling marrow transplants: lack of correlation with GvHD.
Haematologica - 1 Jan 2000
Gaozza E, Piccoli P, Ferrara G B, Bacigalupo A
Abstract excerpt
BACKGROUND: The role of HLA-DP as transplantation antigen in contributing to GvHD is a matter of current debate. HLA-DP, is encoded centromeric to DR-DQ and its alleles are in weak linkage disequilibrium with the rest of the MHC; thus a certain number of HLA matched pairs could be actually DP incompatible to study a possible correlation between HLA-DP matching and GvHD, 24 HLA identical BMT/donor-recipient...
Topics
- Adolescent
- Adult
- Blotting, Southern
- Bone Marrow
- Bone Marrow Transplantation
- DNA
- Female
- Genotype
- Graft vs Host Disease
- HLA-DP Antigens
- HLA-DQ Antigens
- Humans
