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Separation of human adipocytes by size: hypertrophic fat cells display distinct gene expression

5 Jun 2006

Abstract excerpt

ABSTRACT Enlarged adipocytes are associated with insulin resistance and are an independent predictor of type 2 diabetes. To understand the molecular link between these diseases and adipocyte hypertrophy, we developed a technique to separate human adipocytes from an adipose tissue sample into populations of small cells (mean 57.6±3.54 pm) and large cells (mean 100.1±3.94 pm). Microarray analysis of the cell...

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Share to Adipokines, Inflammation, and Metabolic Diseases
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PMID: 16754744
DOI: 10.1096/fj.05-5678fje

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