Article
G80A reduced folate carrier SNP influences the absorption and cellular translocation of dietary folate and its association with blood pressure in an elderly population.
Life sciences - 1 Aug 2006
Dufficy Lisa, Naumovski Nenad, Ng Xiaowei, Blades Barbara, Yates Zoe, Travers Cheryl, Lewis Peter, Sturm Jonathon, Veysey Martin, Roach Paul D, Lucock Mark D
Abstract excerpt
The functional consequences of the G80A RFC SNP on the expressed reduced folate carrier protein were evaluated by looking at the relationship between intake of folate, plasma folate and cellular stores of the vitamin. The effect on homocysteine was also examined. Homocysteine is a thiol that is known to be inversely associated with folate, and which is considered to be both thrombo- and athrogenic. At high...
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