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Article

Prostate derived factor in human prostate cancer cells: Gene induction by vitamin D via a p53‐dependent mechanism and inhibition of prostate cancer cell growth

1 Jun 2006

Abstract excerpt

The secosteroid hormone 1alpha, 25-dihydroxyvitamin D3 (1,25D) has been shown to regulate the growth and differentiation of human prostate cancer (PCa) cells, although the precise molecular mechanisms mediating these effects have not been defined. Previous studies in our laboratory demonstrated that the antiproliferative effects of 1,25D on PCa cells are mediated through the nuclear vitamin D receptor (VDR). In...

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PMID: 16741990
DOI: 10.1002/jcp.20692

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