Article
LDL composition in E2/2 subjects and LDL distribution by Apo E genotype in type 1 diabetes.
Atherosclerosis - 1 May 2007
Murdoch Susan J, Boright Andrew P, Paterson Andrew D, Zinman Bernard, Steffes Michael, Cleary Patricia, Edwards Karen, Marcovina Santica S, Purnell Jonathan Q, Brunzell John D
Abstract excerpt
Apo E plays an important role in chylomicron and VLDL remnant processing, uptake or conversion to LDL. The type of lipoprotein that isolates in the LDL density of E2/2 subjects was investigated and the effect of the apo E isoforms on LDL mass was determined in all genotypes in a large group of Type 1 diabetics. Analysis of the LDL composition of E2/2 homozygotes (n=6) compared to subjects with the common E3/3...
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