Article
Molecular biological approaches to the study of heritable osteoarthritis.
The Journal of rheumatology. Supplement - 1 Feb 1991
Jimenez S A
Abstract excerpt
Certain forms of osteoarthritis (OA) are inherited in a dominant Mendelian pattern suggesting that defects in one or more of the genes encoding for the structural components of articular cartilage may cause premature cartilage degeneration. Recent advances in molecular biology make it possible to...
Topics
- Animals
- Cartilage, Articular
- Cloning, Molecular
- Collagen
- Disease Models, Animal
- Female
- Humans
- Male
- Mice
- Mice, Transgenic
- Mutation
- Osteoarthritis
- Polymorphism, Restriction Fragment Length