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Article

Asi1 is an inner nuclear membrane protein that restricts promoter access of two latent transcription factors.

The Journal of cell biology - 5 Jun 2006

Boban Mirta, Zargari Arezou, Andréasson Claes, Heessen Stijn, Thyberg Johan, Ljungdahl Per O

Abstract excerpt

Stp1 and Stp2 are homologous transcription factors in yeast that are synthesized as latent cytoplasmic precursors with NH2-terminal regulatory domains. In response to extracellular amino acids, the plasma membrane-localized Ssy1-Ptr3-Ssy5 (SPS) sensor endoproteolytically processes Stp1 and Stp2, an event that releases the regulatory domains. The processed forms of Stp1 and Stp2 efficiently target to the nucleus...

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Identifiers

PMID: 16735580
DOI: 10.1083/jcb.200601011
PMCID: PMC2063887

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Asi1 is an inner nuclear membrane protein that restricts promoter access of two latent transcription factors.PMID 16735580Read ↗

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