Article
Purification of human serum paraoxonase/arylesterase. Evidence for one esterase catalyzing both activities.
Drug metabolism and disposition: the biological fate of chemicals - 1 Jan 2000
Gan K N, Smolen A, Eckerson H W, La Du B N
Abstract excerpt
Evidence is presented that human serum contains a single enzyme with both paraoxonase and arylesterase activities. Throughout the steps of purification and after obtaining over 600-fold purification of the enzyme, the arylesterase activity (measured with phenylacetate as the substrate) co-eluted and retained the same ratio of activity to paraoxonase activity as it had in the initial plasma sample. Paraoxon and...
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