Article
Therapeutic potential of dichloroacetate for pyruvate dehydrogenase complex deficiency.
Mitochondrion - 1 Jun 2006
Berendzen Kristen, Theriaque Douglas W, Shuster Jonathan, Stacpoole Peter W
Abstract excerpt
We reviewed the use of oral dichloroacetate (DCA) in the treatment of children with congenital lactic acidosis caused by mutations in the pyruvate dehydrogenase complex (PDC). The case histories of 46 subjects were analyzed with regard to diagnosis, clinical presentation and response to DCA. DCA decreased blood and cerebrospinal fluid lactate concentrations, and was generally well tolerated. DCA may be...
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