Article
Vogt-Koyanagi-Harada-like Syndrome Complicating Pembrolizumab Treatment for Metastatic Melanoma.
Journal of immunotherapy (Hagerstown, Md. : 1997) - 1 Jan 2000
Bricout Marion, Petre Adeline, Amini-Adle Mona, Bezza Widad, Seve Pascal, Kodjikian Laurent, Dalle Stéphane, Thomas Luc
Abstract excerpt
Vogt-Koyanagi-Harada (VKH) syndrome is a rare condition implicating systemic immune reaction against melanocytes. The pathophysiology is unclear. A genetic predisposition has been suggested as HLA-DR4/DRB1*04 is more common among VKH patients. Drug induced VKH syndrome has been reported in advanced melanoma patients receiving immunotherapy, including ipilimumab and adoptive cell transfer of Tumor-Infiltrating...
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