Article
A diallelic RFLP of the CD3-epsilon chain of the clonotypic T-lymphocyte receptor is not associated with certain autoimmune diseases.
Human genetics - 1 Feb 1991
Timón M, Arnaiz-Villena A, Pérez-Aciego P, Morales P, Benmamar D, Regueiro J R
Abstract excerpt
A diallelic restriction fragment length polymorphism of the CD3-epsilon (epsilon) gene, which encodes for an invariant component of the human T-lymphocyte receptor, is observed when using genomic DNA TaqI digests probed with a CD3-epsilon chain cDNA probe. This combination shows two alleles of 9....
Topics
- Alleles
- Antigens, CD
- Antigens, Differentiation, T-Lymphocyte
- Arthritis, Juvenile
- Autoimmune Diseases
- CD3 Complex
- Diabetes Mellitus, Type 1
- Female
- Gene Frequency
- Genotype
- Humans
- Macromolecular Substances
- Male
- Pedigree
- Polymorphism, Restriction Fragment Length
- Receptors, Antigen, T-Cell