Article
A single amino acid exchange shifts the serological reactivity of the novel HLA-B*4442 allele product from HLA-B44 to HLA-B21.
International journal of immunogenetics - 1 Jun 2006
Mrazek F, Fae I, Ambruzova Z, Raida L, Kriegova E, Indrak K, Fischer G F, Petrek M
Abstract excerpt
A novel HLA-B (human leukocyte antigen-B) allele, HLA-B*4442, was identified both in a Czech patient with leukaemia and in his mother. The presence of a novel allele was initially suspected because conflicting results were obtained by serological and DNA typing techniques. The HLA typing using th...
Topics
- Alleles
- Amino Acid Substitution
- Base Sequence
- Czech Republic
- Female
- Gene Expression Regulation, Leukemic
- HLA-B Antigens
- HLA-B44 Antigen
- Humans
- Leukemia
- Male
- Molecular Sequence Data
- Pedigree
- Point Mutation