Article
Identification of the novel allele B*4427 and a confirmatory sequence (B*44022).
Tissue antigens - 1 Apr 2002
Canossi A, Papola F, Liberatore G, Del Beato T, Piancatelli D, Tessitore A, Vicentini M T, Maccarone D, Aureli A, Cervelli C, Di Rocco M, Casciani C U, Adorno D
Abstract excerpt
This report presents a novel allele, HLA-B*4427, which was identified in a bone marrow donor of Caucasian origin, and a confirmatory sequence (B*44022). Sequence analysis revealed the new allele differs from B*44021 by a single nucleotide exchange at position 668 (C-->T), which is located in exon 4. At the protein level, it is the only B*44 variant to produce an Ala in place of a Val at codon 199. Its structure...
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