Article
[Molecular study of retinoblastoma in the Algerian population. Screening of Rb gene in constitutional and tumoral level].
Bulletin du cancer - 1 Feb 2012
Boubekeur Amina, Louhibi Lotfi, Mahmoudi Khadidja, Boudjema Abdallah, Mehtar Nadhira
Abstract excerpt
Inactivation of both alleles of the RB1 gene during normal retinal development initiates the formation of a retinoblastoma (RB) tumor. RB1 screening remains difficult, most of the alterations being unique and randomly distributed throughout the entire coding sequence. In this report, we present the results of a constitutionnal and tumoral RB1 analysis in Algerian population. The detection of RB1 gene deletion or...
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