Article
Evaluation of 10 commercial diagnostic kits for in vitro expressed hepatitis B virus (HBV) surface antigens encoded by HBV of genotypes A to H.
Journal of virological methods - 1 Sept 2006
Mizuochi Toshiaki, Okada Yoshiaki, Umemori Kiyoko, Mizusawa Saeko, Yamaguchi Kazunari
Abstract excerpt
Genetic variability of the hepatitis B virus (HBV) constitutes one of the major challenges for diagnosis of HBV infection. It is plausible that amino acid substitutions in the "a" determinant of the HBV surface antigen (HBsAg) that affect antigenic sites, whether originating from genetic diversity or from mutations in the HBV strain itself, will affect the sensitivity of some diagnostic kits. In fact, recent...
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