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Article

Variable capacity of 13 hepatitis B virus surface antigen assays for the detection of HBsAg mutants in blood samples.

Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology - 1 Apr 2012

Servant-Delmas Annabelle, Mercier-Darty Mélanie, Ly Thoai Duong, Wind Françoise, Alloui Chakib, Sureau Camille, Laperche Syria

Abstract excerpt

BACKGROUND: Natural variation and mutations in the envelope protein (S) of hepatitis B virus can translate into HBsAg variants no longer detectable by conventional HBsAg assays. OBJECTIVES: The aim of the study was to assess the performance of 13 commercial assays currently used for screening and clinical analysis of HBsAg variants. STUDY DESIGN: The limit of detection (LOD) for each assay was established using...

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Identifiers

PMID: 22296790
DOI: 10.1016/j.jcv.2012.01.003

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