Article
Association of interleukin-10 A-592C and T-819C polymorphisms with type 2 diabetes mellitus.
Human immunology - 1 Dec 2005
Chang Yih-Hsin, Huang Chien-Ning, Wu Chuan-Yin, Shiau Ming-Yuh
Abstract excerpt
Type 2 diabetes mellitus (T2DM) is the most common form of diabetes. The association of low interleukin (IL)-10 production capacity with the metabolic syndrome and T2DM was recently established. Approximately 75% of the variation in IL-10 secretion capacity in humans derives from genetic factors that contribute to disease susceptibility. Based on the facts that IL-10 secretion ability is tightly controlled at the...
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