Article
IL-23 promotes tumour incidence and growth.
Nature - 27 Jul 2006
Langowski John L, Zhang Xueqing, Wu Lingling, Mattson Jeanine D, Chen Taiying, Smith Kathy, Basham Beth, McClanahan Terrill, Kastelein Robert A, Oft Martin
Abstract excerpt
Chronic inflammation has long been associated with increased incidence of malignancy and similarities in the regulatory mechanisms have been suggested for more than a century. Infiltration of innate immune cells, elevated activities of matrix metalloproteases and increased angiogenesis and vasculature density are a few examples of the similarities between chronic and tumour-associated inflammation. Conversely,...
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