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IMMUNOLOGY OF MULTIPLE SCLEROSIS

19 Jan 2005

Abstract excerpt

Multiple sclerosis (MS) develops in young adults with a complex predisposing genetic trait and probably requires an inciting environmental insult such as a viral infection to trigger the disease. The activation of CD4+ autoreactive T cells and their differentiation into a Th1 phenotype are a crucial events in the initial steps, and these cells are probably also important players in the long-term evolution of the...

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PMID: 15771584
DOI: 10.1146/annurev.immunol.23.021704.115707

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