Article
[Detection of p53 gene change and serum antibody level in phase II clinical trial of ad p53 gene therapy].
Zhonghua yi xue za zhi - 28 Dec 2005
Zhao Min, Xiao Shao-wen, Yang Jing-xian, Zhang Shan-wen, Lü You-yong
Abstract excerpt
OBJECTIVE: To determine the alteration of p53 gene in tumor tissues and to monitor the immunoresponsiveness to anti adenovirus in patients following treatment of recombinant adenovirus-p53 (Adp53, SBN-1) combined with radiation. METHODS: Tumor tissues were collected from 22 patients with malignant tumors at advanced stage before and after treatment with recombinant adenovirus-p53 (Adp53, SBN-1) combined with...
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