Article
Delays in neuronal differentiation in Mash1/Ascl1 mutants.
Developmental biology - 1 Jul 2006
Pattyn Alexandre, Guillemot François, Brunet Jean-François
Abstract excerpt
The inactivation of a developmental transcription factor may lead to the complete absence of a specific cell type. More commonly, though, it only partially impairs its generation. The modalities of this partial effect have rarely been documented in any detail. Here, we report a novel function for the bHLH transcription factor Ascl1/Mash1 in the generation of the nucleus of the solitary tract (nTS). In Mash1(-/-)...
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