Article
An analysis paradigm for investigating multi-locus effects in complex disease: examination of three GABA receptor subunit genes on 15q11-q13 as risk factors for autistic disorder.
Annals of human genetics - 1 May 2006
Ashley-Koch A E, Mei H, Jaworski J, Ma D Q, Ritchie M D, Menold M M, Delong G R, Abramson R K, Wright H H, Hussman J P, Cuccaro M L, Gilbert J R, Martin E R, Pericak-Vance M A
Abstract excerpt
Gene-gene interactions are likely involved in many complex genetic disorders and new statistical approaches for detecting such interactions are needed. We propose a multi-analytic paradigm, relying on convergence of evidence across multiple analysis tools. Our paradigm tests for main and interactive effects, through allele, genotype and haplotype association. We applied our paradigm to genotype data from three...
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