Article
The interferon gamma gene polymorphism +874 A/T is associated with severe acute respiratory syndrome.
BMC infectious diseases - 4 May 2006
Chong Wai Po, Ip W K Eddie, Tso Gloria Hoi Wan, Ng Man Wai, Wong Wilfred Hing Sang, Law Helen Ka Wai, Yung Raymond W H, Chow Eudora Y, Au K L, Chan Eric Y T, Lim Wilina, Peiris J S Malik, Lau Yu Lung
Abstract excerpt
BACKGROUND: Cytokines play important roles in antiviral action. We examined whether polymorphisms of IFN-gamma,TNF-alpha and IL-10 affect the susceptibility to and outcome of severe acute respiratory syndrome (SARS). METHODS: A case-control study was carried out in 476 Chinese SARS patients and 449 healthy controls. We tested the polymorphisms of IFN-gamma,TNF-alpha and IL-10 for their associations with SARS....
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